Postdoctoral Research Fellowship: Princess Margaret Cancer Centre

150 150 Office of Research Trainees

The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of groundbreaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN’s five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here.

POSTDOCTORAL position is available in the laboratory of Dr. Hakem at the Princess Margaret Cancer Centre/University Health Network, Toronto, Canada. We seek applicants who are highly self-motivated and career-oriented.

Our research focuses on i) gaining a better understanding of the mechanisms that drive cancer development and ii) identification of novel cancer therapeutic strategies.

The lab has excellent track records studying in vivo functions of tumor suppressors (e.g. BRCA1), cancer mechanisms, and signaling pathways involved. Our studies have been published in journals that include, Science (304: 1822-1826), JEM (207: 983-97), Nature Communications (DOI: 10.1038/ncomms12638) and Journal of Clinical Investigation ( and

Our studies are multidisciplinary, and involve genetics, proteomics, transcriptomics, multiomics analyses, genome-wide CRISPR-Cas9 screening, biochemistry and molecular analyses of human cancer cells, mouse models, PDXs, and data from cancer patients.

We are highly committed to expose and target the “Achilles heel” of cancer and identify genetic targets and drugs that eradicate cancer or prevent oncogenesis.

Candidate requirements:

  • PhD or MD/PhD degree obtained within the past 3 years
  • Demonstrated expertise in cell signaling and molecular biology
  • Experience with genome-wide CRISPR-Cas9 screening is desirable
  • Highly self-motivated and creative individual with strong publication records (First author publications)
  • Excellent writing and communication skills
  • Ability to work effectively both independently and as a member of a team is a prerequisite.

Vaccines (COVID-19 and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

More information and apply here.