University Health Network (UHN) is looking for an experienced professional to fill the key role of a Postdoctoral Fellow at Cancer Biology & Imaging Program at Princess Margaret Cancer Centre – preclinical pancreatic research team.
Job Posting #899774
Position: Postdoctoral Fellow
Site: Mars Tower – Princess Margaret Cancer Centre
Department: Cancer Biology & Imaging Program
Reports to: Principal Investigator
Hours: 37.5 per week
Status: Temporary Full-Time ( 1-year contract with potential of renewal)
University Health Network (UHN) is looking for an experienced professional to fill the key role of Postdoctoral Fellow at Cancer Biology & Imaging Program.
Transforming lives and communities through excellence in care, discovery and learning.
The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of groundbreaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.
University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN’s five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here.
The DaCosta Research Lab at the Princess Margaret Cancer Centre (PMCC) (http://dacostalab.ca/) is currently seeking a Postdoctoral Fellow to join our preclinical pancreatic research team.
The successful applicant will be part of a group that uses intravital fluorescence microscopy imaging to study pancreatic cancer initiation, biology, propagation, and response to novel treatment strategies using advanced animal models of disease, for example within the mouse pancreas. The successful applicant will help to study the pancreatic tumor microenvironment in the orthotopic setting including with a focus on tumor vasculature hypoxia, stroma and other key aspects in vivo. An important area of investigation in this role will include the study of novel anti-tumor therapies. A key additional focus area will be on the use of immune- and cell therapies for treatment of pancreatic cancer.
The successful applicant will also collaborate extensively with other leukemia labs across the University Health Network as well as external collaborators. The position status is temporary full-time (1 year) with the potential to extend to permanent full-time based on the candidate’s performance and compatibility with the research team and lab objectives.
- Perform rodent microsurgeries to inoculate cells, install imaging devices, or other procedures as necessary
- Intravital imaging of rodents using various techniques, including but not limited to widefield imaging, confocal and multi-photon microscopy, bioluminescent imaging (BLI), computed tomography (CT), and magnetic resonance imaging (MRI)
- Develop and conduct experiments evaluating new pancreatic treatment strategies, such as immunotherapies, small-molecule inhibitors, transplantations, and radiation
- Produce timely and rigorously written scientific and other publications related to the research undertaken
- Conceive new research directions, build new projects, and participate in grant writing for the lab as necessary
- Troubleshoot, evaluate, and adjust protocols as necessary to improve data quality or in response to experimental needs
- Maintain experimental cell lines and develop new reporter variants as necessary
- Run molecular biology protocols, including but not limited to flow cytometry, ELISA, qPCR, and Western Blot
- Maintain complete and accurate documentation of data generated and work performed on behalf of the lab
- Adhere to Quality Control and Quality Assurance programs to support the effective operation of the lab, and to maintain appropriate laboratory standards
- Contribute to conceiving new ideas for future grants
- Help identify grant opportunities relevant to the lab
- Completion of a PhD from a recognized institution with the last five (5) years
- Minimum three (3) years of experience in cancer biology and immunology, with a publication record, is required
- Excellent animal handling and microsurgery skills are required
- Strong familiarly with molecular and cellular laboratory techniques, e.g. cell culture, virus transduction, ELISA, flow cytometry, immunohistochemistry, is required
- Experience with in vivo imaging techniques, particularly confocal and/or multi-photon microscopy is highly preferred
- Well-developed computer skills and/or the ability to learn new computer programs for analyzing imaging data (e.g. IMARIS, HALO, ImageJ) are an asset
- Excellent problem recognition, critical thinking, organizational, detail-focused, and problem-solving skills
- Ability to work independently and as a team member
- Effective verbal and written communication skills
- Ability to advise and mentor student
Vaccines (COVID-19 and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.
If you are interested in making your contribution at UHN, please apply on-line. You will be asked to copy and paste as well as attach your CV, a copy of your most relevant paper, and the names, email addresses, and phone numbers of three references. All documents should be provided in PDF. You will also be required to complete some initial screening questions.
POSTING DATE: May 26, 2022 CLOSGING DATE: Until Filled
More information and apply here.